WebMar 30, 2024 · On the other hand, the activation of ER stress is involved in the synergistic effect of ferroptosis and apoptosis through the CHOP-p53 upregulated modulator of … WebNov 12, 2024 · Results showed that artesunate induced ferroptosis in DAUDI and CA-46 cells, as evidenced by the protective effect of liproxstatin-1, ferrostatin-1, and …
Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk ... - PubMed
WebFerroptosis is mainly characterized by the accumulation of iron-dependent lipid peroxides and plays a key role in the development and progression of liver diseases, but there are currently few studies on the involvement of ERS in ferroptosis in liver diseases. ... MUELLER K, SUNAMI Y, STUETZLE M, et al. CHOP-mediated hepcidin suppression ... WebFerroptosis-related genes associated with overall survival in the training set were then extracted, and the least absolute shrinkage and selection operator Cox regression model was used to establish an eight-gene signature, comprising ZEB1, PSAT1, NGB, NFE2L2, LAMP2, HIF1A, FH, and CXCL2. Results: The signature exhibited significant … i play by green sprouts
Novel insights into ferroptosis: Implications for age-related diseases
WebNov 16, 2024 · Ischemic stroke is a severe and acute neurological disorder with limited therapeutic strategies currently available. Oxidative stress is one of the critical pathological factors in ischemia/reperfusion injury, and high levels of reactive oxygen species (ROS) may drive neuronal apoptosis. WebJul 1, 2024 · ATF4 also induces the expression of CAAT/enhancer binding protein (C/EBP) homologous protein (CHOP), which is involved in cell death induction [75], [76]. ... Ferroptosis, which is a recently recognized form of programmed cell death characterized by the accumulation of lipid peroxidation through ROS generation via the Fenton reaction ... WebOct 13, 2024 · The ER stress inhibitor, 4-Phenylbutyric acid, was used to confirm that ER stress-CHOP apoptotic signaling is another molecular mechanism of melittin-induced A549 cell death. Thus, our results demonstrate that ferroptosis and ER stress-CHOP signaling are key molecular mechanisms of melittin-induced cell death in lung cancer. i play bluetooth