WebFor example, glycine is cytoprotective in vivo 1997.—Diverse g-aminobutyric acid (GABAA ) receptor modu- against maleate-, ifosfamide-, and cisplatin-induced lators exhibited novel cytoprotective effects and mechanisms of action in rabbit renal proximal tubules subjected to mito- nephrotoxicity in the rat (8, 12, 25), against hypoxic ... WebApr 14, 2024 · Platinum Agents —The use of platinum agents in treating breast cancer can be dated back to the 1970s . Carboplatin and cisplatin are both platinum agents that function by interfering with DNA strand separation, thus inducing cell death in the middle of DNA replication and transcription [ 235 , 236 , 237 ].
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WebHeine oxygenase-1 (HO-1) and HO-2 are cytoprotective enzymes that degrade heme (a potent oxidant) to generate carbon monoxide (CO, a vasodilatory gas that has anti-inflammatory properties), bilirubin (an antioxidant derived from biliverdin), and iron (sequestered by ferritin). WebApr 14, 2024 · Metabolic rewiring is involved in acute myeloid leukaemia (AML) maintenance. Here the authors show that the inhibition of mannose-6-phosphate isomerase in the mannose metabolism pathway sensitizes ... WebA chemotherapy agent used to treat various malignancies, including head and neck malignancy, lymphoma, and testicular tumors, among others. Dexrazoxane. A … durock energy scheda tecnica