Gwas and obesity

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August undefined, 2024

WebFeb 11, 2024 · This GWAS identified 14 PCOS-associated variants reaching a P-threshold of 5×10 −8. From PCOS GWAS, we extracted IV obesity-PCOS associations and relevant information. We also downloaded the full set GWAS summary statistics of PCOS in which data from 23andMe were excluded (due to data availability) (Additional file 1: Table. S5). WebJan 24, 2024 · The obesity- and eBMD-associated TBX15 gene has highly tissue-specific expression unlike its neighbour, WARS2. TBX15 is highly and preferentially expressed in tissues or cell types relevant to the studied GWAS traits. It is associated with WHR adjBMI, WC adjBMI and BMI in many GWAS (Supplementary Table 1). Of all the obesity-trait …

Genetic regulation of the placental transcriptome underlies ... - PLOS

WebJan 25, 2014 · The 39 included studies were reviewed in depth to find SNPs associated with to BMI, waist circumference, waist-hip ratio, fat percentage, fat mass or metabolic … WebGenome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity traits have identified more than 300 single-nucleotide … led chicken coop light

Genes in human obesity loci are causal obesity genes in C

WebMay 1, 2024 · Both body mass index (BMI) obesity and MPDs have substantial heritability, ... We used GWAS summary statistics results for BMI, 38 SCZ, 11 BIP, 39 and MD. 40 The BMI data were obtained from GIANT and UK BioBank (n = 795 640). The MD data were generated by meta-analyzing the Psychiatric Genomics Consortium GWAS and the … WebAug 19, 2015 · Obesity affects more than 500 million people worldwide and contributes to type 2 diabetes, cardiovascular disorders, and cancer. 1 Obesity is the result of a positive energy balance, whereby ... Webof FTO (fat mass and obesity associated gene) with obesity-related traits: a GWAS for anthropometric traits,9 a GWAS for early-onset severe obesity,10 a GWAS for type 2 … led chien

GWAS for BMI: a treasure trove of fundamental insights into

Computational analyses of obesity associated loci generated by

WebSep 20, 2024 · Obesity is a complex multifactorial disorder with genetic and environmental factors. There is an increase in the worldwide prevalence of obesity in both developed … WebMar 23, 2024 · Here, we evaluated whether 32 genome-wide association study (GWAS)-identified variants for obesity were associated with the risk of MM in 4189 German subjects from the German Multiple Myeloma Group (GMMG) cohort (2121 MM cases and 2068 controls) and 1293 Spanish subjects (206 MM cases and 1087 controls). how to edit e signatureWebThe discovery of FTO as the first obesity susceptibility gene. In 2007, within a time period of three months, two studies claimed the discovery of FTO as the first GWAS-identified obesity-susceptibility gene. 8-10 FTO was first discovered through a GWAS of type 2 diabetes in Europeans, comparing 1,924 cases and 2,938 controls. 8 A cluster of single … led chicken walmart

"WebNov 1, 2024 · The GWAS meta-analyses of CRP revealed 58 distinct genetic loci ... Obesity is one of the main determinants of chronic low-grade inflammation in the general population. 37, 38 Adjustment for BMI in the CRP GWAS abolished the association at only three lead variants, suggesting that the genetic regulation of chronic low-grade inflammation is ... " - Gwas and obesity

Gwas and obesity

Shared Genetic Loci Between Body Mass Index and Major ... - JAMA

WebSep 7, 2024 · Author summary Human GWAS have identified hundreds of genetic variants associated with human obesity. The genes being regulated by these variants at the … WebDec 18, 2024 · As obesity is becoming pandemic, morbid obesity (MO), an extreme type of obesity, is an emerging issue worldwide. It is imperative to understand the factors …

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WebFeb 25, 2024 · Clinical characteristics of the 42,393 individuals included in the GWAS are shown in Table 1, and further details categorized by disease status are in Additional file 1: Tables S1–S3. The leading SNPs in association with CAD, IS, and CCD for each group are described in Table 2.The full lists of genome-wide significant (P-value < 5 × 10 –8) and … WebJul 22, 2024 · We also assessed the causal effect of several obesity-related factors including arm fat mass, arm fat-free mass, waist circumference, lipid profile, and glycemic traits on the risk of CTS with summary data from publicly available GWAS (Scott et al., 2012; Willer et al., 2013; Wheeler et al., 2024).

WebDec 31, 2024 · GWAS identified variants associated with birth weight (BW), childhood obesity (CO) and childhood BMI (CBMI), and placenta is a critical organ for fetal development and postnatal health. We examined the role of placental transcriptome and eQTLs in mediating the genetic causes for BW, CO and CBMI, and applied integrative … WebApr 28, 2011 · Results. We analyzed genotype data for 520 cases and 540 control subjects, and performed a GWAS on obesity as a binary trait. We observed a strong association of obesity to the FTO gene, with the most …

WebJan 21, 2024 · Obesity and the distribution of fat within the body are risk factors for cardiometabolic diseases. Here, Rask-Andersen et al. perform GWAS for bio-electrical impedance measurements in UK Biobank ... WebAmong the general population, there is a category of individuals with an innate predisposition to obesity. In recent decades, the increase in the prevalence of obesity and related diseases worldwide indicates the need to study the etiological factors associated with its development. ... Most of the GWAS studies have been conducted in the ...

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WebIf a variant responsible for a GWAS locus also affects gene expression, it is known that the relevant gene could be involved in the biological mechanism of disease pathogenesis. 32 … led chiltupuWebThe Effect of Obesity on the Pharmacokinetics of Pantoprazole in Children and Adolescents The Effect of Obesity on the Pharmacokinetics of ... (39 to less than 42 weeks gestation) … how to edit event reminder on eviteWebBackground Lung function is a heritable complex phenotype with obesity being one of its important risk factors. However, knowledge of their shared genetic basis is limited. Most genome-wide association studies (GWASs) for lung function have been based on European populations, limiting the generalisability across populations. Large-scale lung function … led chimney style bulbWebFeb 2, 2024 · Abstract. Type 2 diabetes mellitus (T2D) and obesity already represent 2 of the most prominent risk factors for cardiovascular disease, and are destined to increase in importance given the global changes in … how to edit epic smart phrasesWebApr 7, 2024 · One plausible, but largely unexplored source of heterogeneity in obesity-associated CVD risk is the impact of body fat distribution (central versus overall obesity), … led chez leroy merlinWebJul 2, 2024 · In the genome era, genome-wide association study (GWAS) is a major and effective approach to discover genes and SNPs that contribute to complex diseases. To date, 46 obesity GWASs and 12 meta-analyses had reported 445 SNPs involved in 389 genes with a significant threshold P < 5×10 −8. The future challenge of obesity genetic … led chez actionWebThe Effect of Obesity on the Pharmacokinetics of Pantoprazole in Children and Adolescents The Effect of Obesity on the Pharmacokinetics of ... (39 to less than 42 weeks gestation) were analyzed. GWAS, phenotype, and clinical data are available in dbGaP. Cases were 1:1 matched with controls according to race and ethnicity, maternal age, and ... how to edit event details on facebook