High-affinity choline transporter 1

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August undefined, 2024

WebFrom substrate specificity to promiscuity: hybrid ABC transporters for osmoprotectants Web22 de jul. de 2024 · The first transporter is high-affinity choline transporter 1 (CHT1) that is expressed in cholinergic neurons and is linked to acetylcholine synthesis, which has a …

Discovery of Compounds that Positively Modulate the High …

Web1 de out. de 2002 · High-affinity choline transporter 1. Gene. ChT. Status. UniProtKB reviewed (Swiss-Prot) Organism. Drosophila melanogaster ... Function. function. Imports choline from the extracellular space to the neuron with high affinity. Rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent (By similarity). By ... WebCHT1 is a member of the SLC5 family of solute transporters and is assigned to SLC5A7 ( 12. ). Its amino acid sequence has 20–25% homology with that of other members of this family ( 13. ). It has been assumed that all members of the family possess a common 13-transmembrane domain core ( 14. how does semiconductor work

Choline transporters, cholinergic transmission and cognition

WebThe high-affinity choline transporter (CHT1), which is specifically expressed in cholinergic neurons, constitutes a rate-limiting step for acetylcholine synthesis. We have found that … Web1 de mai. de 1990 · It is demonstrated that these two affinity states of [3H]HC‐3 binding are totally interconvertible; addition of 0.1 mM ATP in the binding assay medium … Web1 de mai. de 2003 · 1. High-affinity choline transporters (CHTs) have been attributed to CHT1 (also known as SLC5A7), which has a Km of 0.5–5 μM for choline. CHT1 is … how does senate race stand now

Demonstration of Choline Acetyltransferase of a Peripheral Type …

Ca2+‐Dependent, ATP‐Induced Conversion of the …

Web3 de nov. de 2000 · Na +-dependent, high-affinity choline uptake in cholinergic neurons is the rate-limiting step in acetylcholine synthesis.Here we report the molecular cloning and … WebThe transporter protein was cloned and identified by Okuda and co-workers in 2000, and shown to exhibit high-affinity, sodium-dependent choline uptake ( Km ~2 μM) which … photo resultsWebHigh affinity choline transporter 1, Hemicholinium-3-sensitive choline transporter, CHT, Solute carrier family 5 member 7. eCl@ss: 32160702. NACRES: NA.41. Recommended Products. Slide 1 of 10. 1 of 10. Sigma-Aldrich. AV41516. Anti-SLC22A1 (AB1) antibody produced in rabbit. IgG fraction of antiserum. photo retro effects

"WebACh depends on the activity of a high affinity choline trans-porter (CHT1) that is necessary to supply choline for ACh ... Rylett, R.J. & Ferguson, S.S. (2005) Constitutive high-affinity choline transporter endocytosis is determined by a carboxyl-terminal tail dileucine motif. JNeurochem94,86–96. Ribeiro, F.M., Black, S.A., Prado, V.F ... " - High-affinity choline transporter 1

High-affinity choline transporter 1

Molecular properties of the high-affinity choline transporter CHT1

Web1 de jan. de 2005 · Kus, L. et al. Distribution of high affinity choline transporter immunoreactivity in the primate central nervous system. J. Comp. Neurol. 463, 341–357 (2003). Web18 de jan. de 2010 · The cho-1 gene in Caenorhabditis elegans encodes a high-affinity plasma-membrane choline transporter believed to be rate limiting for acetylcholine (ACh) synthesis in cholinergic nerve terminals.

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WebAt high concentrations, choline is transported primarily by a low-affinity and Na + -independent system that is inhibited by hemicholinium-3 (HC3) 10 with a high Ki of … WebThe high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine (ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection and… Expand 15 PDF Deficits in acetylcholine homeostasis, receptors and behaviors in choline transporter heterozygous mice M. Bazalakova, J. Wright, +4 authors

WebThe High-Affinity Choline Transporter: A Critical Protein for Sustaining Cholinergic Signaling as Revealed in Studies of Genetically Altered Mice M. H. Bazalakova & R. D. Blakely Chapter 1676 Accesses 28 Citations Part of the Handbook of Experimental Pharmacology book series (HEP,volume 175) Abstract Web1 de mar. de 2007 · Cholinergic innervation of the heart has been analyzed using cholinergic markers including acetylcholinesterase, choline acetyltransferase (ChAT), and vesicular acetylcholine transporter (VAChT). In the present study we demonstrate putative cholinergic nerves in the rat heart using an antibody to ChAT of a peripheral type …

WebComponents. integral component of membrane / neuronal cell body / plasma membrane. General Function. Choline:sodium symporter activity. Specific Function. Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent. Web29 de jul. de 2014 · Highaffinity choline transporter 1 is involved in choline transport from the extracellular space to the neuron (48). Innexin 2 is required for the regulation of …

WebProtein target information for High affinity choline transporter 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Web10 de jul. de 2015 · Synthesis and release of the neurotransmitter acetylcholine (ACh) is closely linked to the activity of the high-affinity choline transporter protein (CHT), but the impact of insulin receptor signaling and neuronal insulin resistance on these aspects of cholinergic function are unknown. photo retouching software free downloadWeb31 de out. de 2000 · Here we report the molecular cloning and functional characterization of the human high-affinity choline transporter (hCHT1). The hCHT1 exhibits significant … photo retouching pricesWebThe high-affinity choline transporter CHT1 mediates choline uptake, the rate-limiting and regulatory step in acetylcholine synthesis at cholinergic presynaptic terminals.CHT1-medated choline uptake is specifically inhibited by hemicholinium-3, which is a type of choline analog that acts as a competitive inhibitor.Although the substrate choline and … how does sending money with zelle workWebLOC799259 high-affinity choline transporter 1-like [ (zebrafish)] Gene ID: 799259, updated on 4-Nov-2024. how does send on behalf of workWebCTL1 is a high-affinity and CTL2 is a low-affinity Etn transporter We studied the kinetics of Etn transport in monkey COS-7 cells and control (Ctrl) and CTL1 deficient (M1= SLC44A1ΔAsp517 and M2= SLC44A1Ser126) primary human fibroblasts. how does sensitivity toothpaste workWebThe high-affinity choline transporter (ChT) also known as solute carrier family 5 member 7 is a protein in humans that is encoded by the SLC5A7 gene. It is a cell membrane … how does sensory play support developmentWebA choline uptake system with a high affinity for choline has long been assumed to be present in cholinergic neurons. Very recently, the molecular entity for the high-affinity … how does sequencing genes prove evolution