High affinity copper uptake protein 1-like

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August undefined, 2024

Web27 de abr. de 2024 · Multicopper oxidases (MCOs) are blue copper containing proteins and they generally have multiple copper atoms (1 to 6) per molecule [1,2].Diverse enzymes belong to this family of proteins that include laccases, ferroxidases, ascorbate oxidase, bilirubin oxidase and laccase-like MCOs [].MCOs are produced by both prokaryotic as … Web22 de ago. de 2024 · Crystal structure of the high-affinity copper transporter Ctr1 in complex with Cu (I) PDB DOI: 10.2210/pdb6M98/pdb Classification: TRANSPORT PROTEIN Organism (s): Salmo salar, Escherichia coli Expression System: Komagataella phaffii GS115 Mutation (s): Yes Membrane Protein: Yes PDBTM MemProtMD mpstruc …

Deregulated copper transport affects Arabidopsis development …

WebLOC106138791 high affinity copper uptake protein 1-like [] Gene ID: 106138791, updated on 13-Feb-2024. Summary Other designations. high affinity ... Webencode a high affinity copper uptake process and was found to be 29% identical at the primary structure level with Ctr1 from yeast. The human protein was, however, substantially smaller than the yeast protein, being composed of 190 amino acids as compared with 406 amino acids (see Fig. 1). hCTR1 is on the church in windsor ct

Characterization of the Saccharomyces cerevisiae High …

WebIt has been claimed that human copper transporter 1 (hCTR1), the human high-affinity copper transporter, is the major entry pathway for cDDP and related drugs via a mechanism that mimics copper. This is an unexpected property of … WebCopper (Cu) is an essential trace element for growth and development and abnormal Cu levels are associated with anemia, metabolic disease and cancer. Evolutionarily … Web22 de out. de 2024 · One may speculate about copper speciation and/or mechanisms of copper uptake and release. Apart from trafficking in complex with various neurotransmitters, carrier peptides and proteins, or as part of the protein cargo of extracellular vesicles there is also the potential for copper uptake as a result of … church in windsor co

High affinity copper uptake protein 1 - Wikipedia

O15431 - UniProt

WebHigh affinity copper uptake protein 1 Kind protein Organism Humans Protein. Name UniProt ID; High affinity copper uptake protein 1: O15431: Details: Drug Relations … WebProtein target information for High affinity copper uptake protein 1 (house mouse). Find diseases associated with this biological target and compounds tested against it in … church in winterHigh affinity copper uptake protein 1 (CTR1) is a protein that in humans is encoded by the SLC31A1 gene. Copper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, and … Ver mais In 2024, a new autosomal-recessive disease was discovered that is caused by mutations of the CTR1 gene. The disease is characterized by profound deficiency of copper in the central nervous system and presents with … Ver mais • Solute carrier family Ver mais • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". … Ver mais church in winterstown pa

"WebHigh affinity copper uptake protein 1 Gene SLC31A1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 190 Protein existence Evidence at … " - High affinity copper uptake protein 1-like

High affinity copper uptake protein 1-like

X-ray structures of the high-affinity copper transporter Ctr1

WebThe affinity measured by Km value for the drugs transported by their corresponding DTs were unified to the unit of micromolar 4. 2D and 3D Structures of Small Molecular Drugs The structures of the small molecular drugs transported by DTs were drawn and were standardized in the .sdf format (both 2D and 3D) 5. WebBecause copper uptake at the cell membrane is a crucial step in copper acquisition, yeast genes encoding the high affinity copper transport proteins are tightly regulated in response to copper levels to ensure …

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WebHigh affinity copper uptake protein 1 Gene SLC31A1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 190 Protein existence Evidence at … Web13 de abr. de 2024 · Expression and affinity purification of recombinant proteins. Recombinant proteins were purified by Ni-NTA affinity column (detected by western blot). The gel was stained with Coomassie brilliant blue G250 (CBB G250). (A) Western blot analyses of the recombinant Rh14-3-3ζ and Rh14-3-3ε protein.

Web15 de abr. de 2024 · High affinity copper uptake protein 1 (pig) Protein Target - PubChem Apologies, we are having some trouble retrieving data from our servers... Web15 de abr. de 2024 · Protein target information for High affinity copper uptake protein 1 (pig). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

WebHigh affinity copper uptake protein 1: Synonyms: Copper transporter 1; Solute carrier family 31 member 1; hCTR1; Gene Name: SLC31A1: Protein Type: Transporter: Biological Properties; ... structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture. Web7 de mai. de 2024 · Cuprizone administration induces mitochondrial enlargement, severely alters metabolic rates, and impairs oxidative phosphorylation by reducing mitochondrial enzymes that contain copper as a cofactor, such as monoamine oxidase [ 27] and cytochrome c (Cyt c) oxidase [ 28, 29] in the brain of mice.

WebHigh affinity copper uptake protein 1 Alternative names Copper transporter 1 ( rCTR1) Liver regeneration-related protein LRRGT00200 Solute carrier family 31 member 1 …

WebGene ID: 100178573, updated on 26-Oct-2024. Summary Other designations. high affinity copper uptake protein 1-like church in winter park flWebGene ID: 102804936, updated on 5-Feb-2024. Summary Other designations. high affinity copper uptake protein 1-like church in windsorWeb11 de abr. de 2024 · Several lines of evidence presented here strongly suggest that the first histidine (His43) upstream from TMD1 is absolutely required for the copper transport activity of COPT1 protein. Firstly, deletion of 43 residues, but not 41 residues, of the extracellular N-terminus, completely blocked high affinity copper uptake of COPT1. church in winnsboroWeb1 de jan. de 2024 · This high-affinity copper transporter takes up Cu + from the intestinal lumen to the epithelial cell, in an energy-independent manner [2], [3]. CTR1 is the major copper importer present on the apical site of enterocytes, but conflicting reports have also shown a possible role of DMT1 in copper transfer into intestinal cells. church in winnipegWeb21 de abr. de 2011 · COPT7 alone could mediate a high-affinity Cu uptake in the yeast mutant. None of the seven COPTs alone or in cooperation could complement the phenotypes of S. cerevisiae mutants that lacked the transporter genes either for iron uptake or for zinc uptake. church in windsor californiaWebThese high-affinity copper transporters exist in all eukaryotes and their discovery has provided new insights into how cells acquire and regulate this essential nutrient. The … church in winchester vaWeb28 de nov. de 2024 · DOI: 10.3389/fmolb.2024.1055356 Abstract More than a decade ago, studies on cellular cisplatin accumulation via active membrane transport established the role of the high affinity copper uptake protein 1 (CTR1) as a main uptake route besides passive diffusion. church in winchester ma