Inf2 protein
WebThe formin family of proteins is united by their ability to nucleate actin filaments, overcoming the rate-limiting step of actin polymerization. In recent years, the Higgs lab has extensively studied inverted formin 2 (INF2). In addition to nucleating new actin filaments, INF2 enhances the elongation of actin filaments and accelerates actin ... Web21 feb. 2013 · INF2 colocalized with the myelin and lymphocyte protein (MAL; 188860) in …
Inf2 protein
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WebDuke University. Aug 2016 - Present6 years 9 months. Raleigh-Durham, North Carolina Area. • Developing algorithms for computational protein structure design with the Donald Lab as a PhD ... Web9 dec. 2015 · Role of protein 4.1R in cell migration and tubulin cytoskeleton organization. ... The FH2 domain, which was mapped as the INF2 region involved in centrosome repositioning, was able to mediate the formation of stable, detyrosinated microtubules and to restore centrosome translocation in DIA1-, ...
Web15 jan. 2008 · Description. A form of Charcot-Marie-Tooth disease, a disorder of the … Web8 jan. 2024 · One SRC-like tyrosine kinase trafficked by INF2, lymphocyte-specific protein tyrosine kinase (LCK), has previously been shown to play a role in tumor metastasis (Andrés-Delgado et al., 2010; Mahabeleshwar and Kundu, 2003)—perhaps one of the many reasons EVT invasion is frequently compared to the metastatic invasion in cancer.
Web29 jul. 2024 · Using immunohistochemistry, we demonstrated expression of formin … WebProteins (UniProtKB) Species (Proteomes) Protein clusters (UniRef) Sequence archive …
Web29 feb. 2016 · Mutations in inverted formin 2 (INF2) cause focal segmental glomerulosclerosis (FSGS) a major cause of end-stage kidney disease. In the present study, we show that disease associated mutations reduce INF2 auto-inhibition and cause increased binding to monomeric G-actin, profilin 2 and the F-actin capping protein, CapZ …
Web29 jul. 2024 · Knockdown of individual formins mDia1, mDia2, FHOD1 and INF2 significantly reduced migration in most studied cell lines. Among the studied formins, knockdown of INF2 generated the greatest reduction in motility in vitro. Using immunohistochemistry, we demonstrated expression of formin proteins FHOD1 and INF2 in glioblastoma tissues. sigmashield 1200 sdsWebFunctional Associations. INF2 has 4,100 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 78 datasets. the print point waterfordWebFor INF2-MAL2 pull-down assays, the HepG2 cell soluble (S) and insoluble (I) fractions obtained by centrifugation to equilibrium of HepG2 cell extracts in 25 mM Tris–HCl, pH 7.5, 150 mM NaCl, 5 mM EDTA, 1% Triton X-100 were incubated overnight at 4°C with 10 g of GST or GST-INF2 proteins immobilized on GSH- the print podcastWeb13 okt. 2024 · As 5 min is not likely to be sufficient time to alter the concentration of INF2 via the induction of protein synthesis (and we additionally confirmed that the protein synthesis inhibitor ... theprint profileWebSTK16 (Ser/Thr kinase 16, also known as Krct/PKL12/MPSK1/TSF-1) is a myristoylated and palmitoylated Ser/Thr protein kinase that is ubiquitously expressed and conserved among all eukaryotes. STK16 is distantly related to the other kinases and belongs to the NAK kinase family that has an atypical activation loop architecture. As a membrane … sigmashield 1200 product data sheetWebINF2 encodes a formin protein that interacts with the Rho-GTPase CDC42 and myelin … the print plugWeb20 aug. 2024 · Mutations in INF2 are frequently responsible for focal segmental glomerulosclerosis (FSGS), which is a common cause of end stage renal disease (ESRD); additionally, they are also connected with Charcot-Marie-Tooth neuropathy. INF2 encodes for inverted formin 2. This protein participates in regulation of the dynamics of the actin … the print post newark